Name: Advanced+ Joint Liquid
Brand: Wuffes
Availability: InStock

Made in the USA*
*from globally sourced ingredients
Scientifically Formulated
3rd Party Tested
The 90-Day Promise
No Artificial Colors
No Artificial Preservatives

80% of Dogs Over 8 Suffer from Joint Issues*

As dogs get older, their everyday movement becomes harder. It’s only natural. We built Advanced+ Joint Liquid to help their everyday feel even better.

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Percentage of dogs with joint issues, by age in years
Dog Age (Years)	Percentage (%) with Joint Issues
5	20
6	36
7	50
8	80

*Source: Johnston, S.A. (1997) 'Osteoarthritis', Veterinary Clinics of North America: Small Animal Practice, 27 (4), pp. 699-723. Doi: 10.1016/s0195-5616(97)50076-3.

UC-II® Collagen does the work

91%reduction in joint discomfort upon limb manipulation*
78%reduction in exercise-associated lameness*
62%reduction in joint discomfort*

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*After 120 days usage. Source: D'Altilio, M. et al. (2007), ‘Therapeutic efficacy and safety of undenatured Type II Collagen singly or in combination with Glucosamine and Chondroitin in arthritic dogs’, Toxicology Mechanisms and Methods. UC-II® is a Lonza trademark.

Benefits

Comprehensive daily support for the bones and joints that keep your dog moving.

Keeps joints moving freely through their full range of motion – every walk, every run, every stride.

Maintains the tendons and ligaments that hold the joint together and keep everything stable and supported.

Keeps them moving the way they're built to.

A Bernese mountain dog jumps up towards a man's raised hand in front of a white porch

More 5 star reviews than anyone else? That's us.

4.5

*Based on 5 star Trustpilot reviews among US dog supplement brands as of September 2026. Source: Trustpilot.

Results Timeline

Our supplements are built for the long game. The more consistent you are, the harder they work.

A woman pours liquid from a Wuffes bottle into a food bowl while a black-and-white spaniel sits waiting on the lawn

WEEK 1LAY THE GROUNDWORK

UC-II® Collagen gets absorbed quickly and starts its work in the gut from day one. Things are in motion.

A tricolour spaniel lies panting beside a raised garden bed while its owner strokes its head, with leafy plants and orange flowers behind

WEEKS 2–3SOMETHING'S STARTING TO SHIFT

UC-II® Collagen's benefits start to kick in even more and Boswellia Serrata starts actively supporting the inflammatory pathway. Now, you’ll start to see your dog moving even easier. A little more flexibility. Moving a little quicker.

A black-and-white spaniel runs towards the camera with its tongue out, the background blurred with motion

WEEKS 4–6YOU'LL SEE IT. THEY'LL FEEL IT.

At this point, your dog’s joints are getting great structural and immune support. So, they’ll be moving more freely, without experiencing as much discomfort.

A black-and-white spaniel jumps up at a green Wuffes "Unleash the Hound" tote bag held by its owner on a dirt track

WEEKS 6–8IN FULL FORCE

All types of support – structural, immunity, joint fluid – are now at their most stable and consistent. Daily use is what’s going to keep it up, so keep up the good work.

UC-II® is a Lonza trademark.

Remember: Every dog is different. Size, age, where they're starting from – it all plays a part. Daily use is what makes the difference. These are supplements, not quick fixes.

Why we built it

Some dogs need something stronger. Some don't do chews. We built for both. Powered by UC-II® Collagen – a smarter, more targeted approach to joint care.

A golden cocker spaniel stands on its hind legs beside its owner in front of a chalkboard menu and an American flag

How we raise the bar

More UC-II® Collagen than others for big dogs

The clinically studied concentration of UC-II® Collagen for big dogs in the US is in every bottle. And it helps reduce joint discomfort by 62%.*

The fussy dog formula

Some dogs won't touch a chew. Joint Liquid is built with clinically tested ingredients – just in a format they can't argue with. Case closed.

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UC-II® is a Lonza trademark.

Real dogs. Real results.

The moment you notice your dog is back to themselves – we never get tired of hearing it.

A small black-and-grey terrier mix lies on a grey wicker outdoor sofa beside a lime cushion

Advanced+ Joint Liquid

Keillor

13 years old

Once he started this liquid, he picked up his pace, started acting like he was in a lot less pain and was more joyful. I'd recommend it to anyone with a senior dog.

Jennifer W.

Advanced+ Joint Liquid

Staffordshire Terrier

10–12 years old

I have noticed improvement on my older dog's movement and overall attitude. She sleeps better and don't complain about pain as much. We also watch her diet and exercise as often as the weather allows. It's been a game changer!

Ana D.

A black-and-tan dog stands in a field of clover holding a red spiky ball

Advanced+ Joint Liquid

Border Collie

9 years old

It was almost an immediate difference! Now after 6 months she's back to her normal energetic self, running for the ball, barking at outsiders all day with almost zero limping! I'm so thankful for the years and quality of life it's given back to her.

Amy W.

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TRUSTED BY OVER 1.3 MILLION DOG PEOPLE. You're in good company.

A woman named Melissa introducing herself and her dog, Izzy, to camera at home

Advanced+ Joint Liquid

$64.99

$34.99

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Veterinarian Dr. Tiffany Ruiz in a black top in front of a bookshelf, introducing herself to camera

Advanced+ Joint Liquid

$64.99

$34.99

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A woman named Riley in a blue t-shirt sitting beside her seven-and-a-half-year-old yellow Labrador

Advanced+ Joint Liquid

$64.99

$34.99

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Veterinarian Dr. Andrew, in a blue shirt with a stethoscope, holding a brown and white dog in his lap as he introduces himself

Advanced+ Joint Liquid

$64.99

$34.99

Try now

A woman in a denim jacket on her sofa introducing her two dogs, Lily and Jack

Advanced+ Joint Liquid

$64.99

$34.99

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Dr. Christina, an animal chiropractor in a black t-shirt, introducing herself to camera

Advanced+ Joint Liquid

$64.99

$34.99

Try now

Advanced+ Joint Liquid

$64.99

$34.99

Try now

Advanced+ Joint Liquid

$64.99

$34.99

Try now

Advanced+ Joint Liquid

$64.99

$34.99

Try now

Advanced+ Joint Liquid

$64.99

$34.99

Try now

Advanced+ Joint Liquid

$64.99

$34.99

Try now

Advanced+ Joint Liquid

$64.99

$34.99

Try now

The Wuffes Standard™

Scientific principles we obsess over, because every milligram matters.

The right ingredients

UC-II® Collagen, Glucosamine, Boswellia Extract and more.
The right concentrations

3,380mg of actives per ounce.
The right blends

Each ingredient targets a specific area, but they work together to achieve the same goal; better joint health.
Glucosamine HCl, Chondroitin and MSM support cartilage, joint structure and connective tissue. Boswellia Serrata supports a healthy inflammatory response at the joint level. And UC-II® Collagen supports a balanced immune response to joint cartilage.
UC-II® is a Lonza trademark.

What's inside?

Clinically-tested ingredients picked for a purpose and crafted into a blend that makes use of every milligram.

Glucosamine
HCl

Glucosamine
HCl

JOINTS · MOBILITY · CARTILAGE

Supports healthy cartilage – the natural cushioning between your dog's bones – by feeding the molecules that absorb shock and keep joints moving freely.

PRODUCTSADVANCED HIP & JOINT CHEWS ADVANCED+ JOINT LIQUID

Chondroitin

Chondroitin

MOBILITY · JOINTS · STRUCTURE

Supports new cartilage production and protects existing cartilage from breaking down – so the joint stays strong and structured.

PRODUCTSADVANCED HIP & JOINT CHEWS ADVANCED+ JOINT LIQUID

Boswellia
Serrata

Boswellia
Serrata

MOBILITY · JOINTS · INFLAMMATORY RESPONSE

Supports a healthy inflammatory response at the joint level – helping maintain joint comfort, flexibility and mobility, by blocking the enzyme responsible for creating inflammatory compounds that cause discomfort.

UC-II®
Collagen

UC-II®
Collagen

MOBILITY · JOINTS · CARTILAGE

Protects healthy cartilage by essentially "training" the immune system to stop attacking your dog's cartilage. It's a smarter, more targeted approach – and the hero of our formula.

*UC-II® is a Lonza trademark.

MSM

MSM

MOBILITY · JOINTS · CONNECTIVE TISSUE

Methylsulfonylmethane is a compound that is naturally produced by the body but is also found in a lot of fresh foods. MSM helps to improve blood flow to the affected areas and helps reduce discomfort and stiffness.

PRODUCTSADVANCED+ JOINT LIQUID ADVANCED HIP & JOINT CHEWS

ACTIVE INGREDIENTS:

Per fl oz: Glucosamine HCl 1500mg, MSM 600mg, Chondroitin Sulfate 600mg, Boswellia Serrata Extract (65% Boswellic Acid) 600mg, UC-II® Collagen 80mg.

INACTIVE INGREDIENTS:

Organic Vegetable Glycerin, Purified Water, Natural Beef Flavoring, Potassium Sorbate, Xanthan Gum, Citric Acid.

UC-II® is a Lonza trademark.

Not all supplements are created equal

3,380mg of actives
per ounce

A glossy liquid drop split down the middle, amber on the Wuffes side and grey on the other, contrasting Wuffes Advanced+ Joint Liquid with other joint supplements

Others

Minimal actives.
More fillers.

How Wuffes Advanced+ Joint Liquid compares with other joint supplements
	What the liquid does	OTHERS
Yes	UC-II® Collagen at its full clinical concentration	No
Yes	Concentrated liquid format for quicker results	No
Yes	Works in harmony with your dog's natural immune system	No
Yes	Highly concentrated Boswellia Serrata standardized to 65%	No

UC-II® is a Lonza trademark.
Remember: Every dog is different. Size, age, where they're starting from – it all plays a part. Daily use is what makes the difference. These are supplements, not quick fixes.

The vet advisory board that actually advises

Our vet partners don't just recommend our supplements. They know what you are really dealing with – the problems that don't go away and what good actually looks like. That knowledge shapes everything we make.

Dr. Tiffany Ruiz Da Silva, a Wuffes veterinary advisor, in a black vet jacket with a stethoscope, holding two Yorkshire terriers — Dr. Tiffany Ruiz Da SilvaVMD, cVMA | Canine Nutrition

Dr. Jennifer Repac, a Wuffes veterinary advisor, in a white lab coat with her arms folded — Dr. Jennifer RepacDVM, DACVSMR, CVA, CCRT, CVCH | Sports Medicine & Rehabilitation

The standards behind every supplement

Certified against the industry's gold standard

The NASC exists because pet supplements deserve the same rigour as the ones you'd take yourself.

We're proud to carry the NASC Quality Seal – awarded only to brands that pass a comprehensive independent audit and maintain ongoing compliance with rigorous quality standards.

It's the clearest signal a dog parent has that what's on the label is what's in the product. It can't be purchased. It has to be earned.

Every formula we make is held to the same three-part standard: The right ingredients, at the right concentrations, in the right blends.

Not because it's the easiest way to make a supplement. But because it's the right way to make one that works.

It's the difference between a product that looks good on a label and one that makes a real difference to your dog.

Every Wuffes formula is independently tested for quality, purity and potency once it leaves our facility.

It's an extra layer of accountability we built into our process – not because we're required to, but because if you're going to give something to your dog every day, it has to be exactly right.

Processing can degrade active ingredients, reducing their potency before the product even reaches your dog.

We test every formula post-manufacturing to verify that what we formulated is what survived. If the active ingredients didn't make it through intact, neither does the product.

Every ingredient in every Wuffes formula is there for a specific, documented reason. No wheat, corn, soy or potato. No unnecessary binders or fillers. No artificial colors or flavorings.

Where flavoring is needed, we use whole food flavors such as natural beef flavoring, not synthetic alternatives or derivatives.

Nothing enters the formula without justification. Nothing is there to bulk out the product or reduce cost.

A supplement your dog won't eat is no supplement at all – every dog parent knows that feeling.

The industry's answer to palatability (taste) testing is laboratory dogs. Kept in controlled environments, used specifically for this purpose. We don't think that's the right way to do it, and we never have.

So before any Wuffes formula goes to market, it's tested by real dogs, sourced from our own large community of dog parents. Simply put, if dogs don't like it, it doesn't make the cut.

Supplements take time to work. The active ingredients need time to build up, absorb, and begin working at a cellular level.

You make a commitment to your dog, so here's ours to you. 90 days to try it, stick with it and if you're not happy with the results – we'll make it right.

We're proud that less than 1% of our customers ever need to take us up on it.

Every Wuffes supplement is manufactured in certified facilities in the United States, held to some of the most rigorous production standards in the world.

FDA-registered, cGMP-compliant facilities where every stage of production, from raw material intake to finished product, is documented, audited, and held to a consistent standard.

*with globally sourced ingredients

A man in a brown hat sits on wooden porch steps feeding a chew to a curly-coated black dog, a jar of Wuffes chews in his other hand

What everyone else says

4.5

4.8

4.9

REAL DOGS. REAL REVIEWS.

From dog people, for dog people.

Not sure where to start? We can help.

Every dog is different. Tell us about yours and we’ll point you to the formula that fits. It takes less than a minute and saves you the guesswork. Plus you’ll get $5 off your first order.

Find my dog’s formula

FAQs

For all product FAQs please head to our FAQs page

Active Ingredients (per oz)

Glucosamine HCl 1500mg, MSM 600mg, Chondroitin Sulfate 600mg, Boswellia Serrata Extract (65% Boswellic Acid) 600mg, UC-II® Collagen 80mg.

Inactive Ingredients

Organic Vegetable Glycerin, Purified Water, Natural Beef Flavoring, Potassium Sorbate, Xanthan Gum, Citric Acid

Caution: If animal's condition worsens or does not improve, stop product administration and consult your veterinarian. Safe use in pregnant animals or animals intended for breeding has not been proven. Administer during or after the animal has eaten to reduce incidence of gastrointestinal upset. An examination from a veterinarian is recommended prior to using this product.

Use your pet’s weight to follow the daily recommended guidelines below. We recommend that you feed it with or after one of their daily meals. For the first 4 weeks, consider splitting the recommended amount in half and giving it over two different times. This will help your pet adjust to this addition to their diet.

Under 20lbs: 1 tsp daily
21-40lbs: 2 tsp daily
41-60lbs: 3 tsp daily
61-80lbs: 4 tsp daily
81-100lbs: 5 tsp daily
Over 100lbs: 6 tsp daily

Designed to enhance joint health, our powerful formula helps reduce occasional discomfort while enhancing joint mobility. It features scientifically-proven ingredients like Glucosamine, MSM, Chondroitin Sulfate, UC-II® Collagen, and Boswellia Serrata. Together, these ingredients offer a multi-faceted approach to joint health, enhancing the structural integrity of joints and connective tissue in dogs of all ages. Our liquid formula is designed to:

Enhance bone & joint health
Ease joint stiffness due to daily activity
Provides building blocks for synovial fluid, cartilage and connective tissues
Enhances tissue pliability
Provides bone reinforcing factors

Our joint liquid is suitable for pets over 6 months of age.

Our Joint Liquid can be stored at room temperature for up to three months. For optimum freshness, we recommend storing it in the fridge.

Our formula contains bovine sourced ingredients and should not be used in animals with beef allergies or sensitivities.

Our Joint Liquid contains active compounds which can cause gastrointestinal upset when consumed in large doses. If your pet consumes more than they should, you may see loose stools and/or minor vomiting for a day or so. These symptoms subside quickly but should they persist, please consult your vet.

Joint supplements are important because they help support and maintain joint health, particularly in aging dogs. They can also be beneficial for breeds that are prone to joint discomfort as they help maintain normal healthy cartilage and joint function.

With 1 in 5 dogs developing joint discomfort in their lifetime (reference), it’s very important for pet parents to look out for and recognize signs of joint discomfort. Some signs to look out for include:

Limping
Difficulty standing up and/or lying down
Shaking legs
Uneven weight bearing and/or favoring one side

These symptoms are also very common signs of other diseases or disorders. If you observe your pet to have one or more of these symptoms, please consult your veterinarian.

Absolutely. As long as you follow our dosage guidelines, our joint liquid can be safely used in conjunction with other supplements, including any NSAIDs that your vet may have prescribed for your pet’s joint disease. If your pet takes prescription medication, always consult your vet before introducing new supplements to your pet’s diet.

No, our joint liquid is not cat safe as some ingredients do not have proven safety indices in cats. It is for use in dogs only.

(Note: An account will only be available if you've completed your purchase as a "subscription." One-time orders will not create an account.)

You can click on the user icon at the top right of the page, next to the shopping cart, or use the "Manage my subscription" option in our Help Center. Enter the email associated with your Wuffes purchase and a one-time login code will be sent to you — check your spam folder if it does not arrive.

We’re proud to say that every Wuffes product is made right here in the USA—crafted with care and held to the highest quality standards. We use a mix of domestically and globally sourced ingredients, carefully selected for their safety, effectiveness, and benefits for your pup’s health.

From production to packaging, we’re committed to delivering trustworthy supplements that you (and your dog) can feel good about.

We know your furry friend can't wait to receive their Wuffes, and with all that tail-waggling, all they mean is "Is it here yet?!". Don't worry, we won’t keep you waiting! All orders placed before noon are shipped on the same day, while all other orders will ship within 1 business day.

e.g. If your order is placed on a Friday at 9:00 am, your order will be shipped the same day. If your order is placed on a Friday at 2:00 pm, your order will be shipped until the next Monday.

If you’re not satisfied with your purchase, please email hello@wuffes.com and our customer service will be happy to help.

Where Does Wuffes Ship From?

Wuffes orders ship from the USA. We fulfill orders from three warehouses located in Tracy, CA, Addison, IL, and Atlanta, GA.

More zoomies on the way?

We totally get wanting the best for your mama-to-be! Since our supplements haven’t been tested on pregnant or nursing dogs, we recommend checking with your vet first to make sure it’s the safest choice for her and her pups.

Advanced+ Joint Liquid

Ingredients

Results Timeline

Serving Guide

80% of Dogs Over 8 Suffer from Joint Issues*

UC-II® Collagen does the work

Benefits

1Supports Everyday Bone and Joint Health

2Helps Maintain Normal Joint Flexibility

3Supports Connective Tissue Function

4Maintains Normal Mobility

More 5 star reviews than anyone else? That's us.

Results Timeline

WEEK 1LAY THE GROUNDWORK

WEEKS 2–3SOMETHING'S STARTING TO SHIFT

WEEKS 4–6YOU'LL SEE IT. THEY'LL FEEL IT.

WEEKS 6–8IN FULL FORCE

Why we built it

How we raise the bar

Real dogs. Real results.

TRUSTED BY OVER 1.3 MILLION DOG PEOPLE. You're in good company.

The Wuffes Standard™

The right ingredients

The right concentrations

The right blends

What's inside?

GlucosamineHCl

Chondroitin

BoswelliaSerrata

UC-II®Collagen

MSM

See all ingredients

Not all supplements are created equal

The vet advisory board that actually advises

The standards behind every supplement

Certified against the industry's gold standard

NASC Certified

The Wuffes Standard™

Third Party Tested

Active Ingredient Verified

Ingredient Integrity Verified

Community Taste Tested

The 90-Day Promise

Made in USA*

What everyone else says

REAL DOGS. REAL REVIEWS.

Not sure where to start? We can help.

FAQs

What are the full ingredients?

How much should I give my pet?

How can it benefit my pet?

How old does my dog have to be?

How should it be stored?

Does it contain any allergens?

Can my pet overdose?

Do pets need joint supplements?

How do I know if my pet needs a joint supplement?

Can it be used with other supplements or prescription medication?

Is it safe for cats?

Where can I find my account?

Where are your products made?

How long do orders take to ship?

How do I return an item?

Where are your products shipped from?

Can I give Wuffes supplements to a pregnant dog?

Glucosamine
HCl

Boswellia
Serrata

UC-II®
Collagen