Calming Chews
180g / 6.35oz / 60 chews
Relora® is used under license.
Premium, Ethically-Sourced Ingredients
Made in USA
GMP Certified
In line with FDA CVM Guidelines
90 Day Satisfaction Guarantee
Premium, Ethically-Sourced Ingredients
Made in USA
GMP Certified
In line with FDA CVM Guidelines
90 Day Satisfaction Guarantee
Dr. Meghan Barrett
DVM, cVMA, CCRT, CVFT, FFCP, CCVN
Dr. Tiffany Ruiz-Da Silva
VMD, cVMA
Smudge
Wuffes Calming Chew Superfan
Charlie
Wuffes Calming Chew Superfan
Dave
Wuffes Calming Chew Superfan
Here's a crazy statistic for you – almost 50% of dogs suffer from fear and anxiety.*
Things like a simple doorbell ringing, car ride or trip to vet can feel like a complete sensory overload.
So, how can you tell if your pup is stressed out? See if any of the signs below check out:
Barking or Whining
Lip Licking or Tail Chasing
Pacing or Restlessness
Destructive Behaviour
Frequent Peeing Indoors
Hiding or Attempting to Escape
Ears Pinned Back or Tail Tucked
Trembling or Shaking
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Some highly intelligent and sensitive breeds are especially prone to these behaviors:
Some highly intelligent and sensitive breeds are especially prone to these behaviors:Border Collies • German Shepherds • Australian Shepherds • Vizslas • Italian Greyhounds • Chihuahuas • Toy Poodles • Shetland Sheepdogs • Weimaraners
*Source: Texas A&M College of Veterinary Medicine.
Daily Support, Made Simple
Formulated with active ingredients at meaningful amounts, every Wuffes chew is designed to deliver real benefits, not empty promises.
Directions for Use
0-35 lbs
1 soft chew daily
36-65 lbs
2 soft chews daily
66-100 lbs
3 soft chews daily
101-120 lbs
4 soft chews daily
Over 121 lbs
5 soft chews daily
We recommend giving supplements as part of their normal routine
What Are They Stressed About?
Everyday stresses?
For everyday stresses, take the chews daily.
Specific stressful situation?
For stressful situations you know are coming up, take chews 3-4 weeks before.
What You'll Start to See
Our chews are scientifically formulated with clinically tested ingredients to bring out the best in your pup.
Promotes relaxation, without sedation
Supports emotional balance and stress regulation
Helps promote calm behaviour
Maintains normal cortisol levels
In a Sea of Products, Why Trust Us?
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EVERYONE ELSE 
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COST PER CHEW |
$0.41 |
$0.44 – $1+ |
TOTAL ACTIVE INGREDIENTS PER CHEW |
💪🏻 |
👎 |
CLINICALLY STUDIED AMOUNT |
🧪 |
❌ |
HIGHLY CONCENTRATED |
✅ |
❌ |
VETERINARIAN APPROVED |
✅ |
❌ |
NASC APPROVED 
|
✅ |
🤷🏼 |
MADE IN USA |
✅ |
💩 |
MONEY-BACK GUARANTEE |
✅ |
🤷🏼 |
The ingredients in our Calming Chews have been scrutinized in thousands of studies, and are meticulously selected for their combined effect to reduce stress and promote calm.
Relora®
Featured In:
Featured In:
Featured In:
Featured In:
The Research
- Demonstrated to help dogs stay calm during noise-related stressful events, such as thunderstorms and fireworks (DePorter et al., 2012)
- Supports overall behavioral relaxation and improved mood during times of stress (DePorter et al., 2012)
- Shown to help maintain cortisol balance and calm behavior during times of occasional stress (Garrison et al., 2008)
ACTIVE INGREDIENTS PER CHEW, (3g)
- Relora® – 75mg
- Chamomile Extract – 50mg
- GABA (Gamma-Aminobutyric Acid) – 35mg
- L-Tryptophan – 35mg
INACTIVE INGREDIENTS
- Apple Cider Vinegar, Brewers Dried Yeast, Coconut Glycerin, Coconut Oil, Dried Whey, Honey, Mixed Tocopherols, Molasses, Pollock Oil, Pork Spray Dried Liver, Rosemary Extract, Sunflower Lecithin, Tapioca Starch.
Check out our Ingredients Glossary for more info.
Relora® is used under license.
The Research
- Shown to support a healthy stress response and help maintain normal cortisol patterns associated with stress (Keefe et al., 2018; Saadatmand et al., 2024).
- Associated with promoting relaxation, emotional balance, and calm behavior during periods of occasional stress (Saadatmand et al., 2024; Alvarado-García et al., 2024).
- Research suggests chamomile supports normal neurological function and relaxation pathways through its natural bioactive compounds, including apigenin (Jabri et al., 2022; El Mihyaoui et al., 2022).
ACTIVE INGREDIENTS PER CHEW, (3g)
- Relora® – 75mg
- Chamomile Extract – 50mg
- GABA (Gamma-Aminobutyric Acid) – 35mg
- L-Tryptophan – 35mg
INACTIVE INGREDIENTS
- Apple Cider Vinegar, Brewers Dried Yeast, Coconut Glycerin, Coconut Oil, Dried Whey, Honey, Mixed Tocopherols, Molasses, Pollock Oil, Pork Spray Dried Liver, Rosemary Extract, Sunflower Lecithin, Tapioca Starch.
Check out our Ingredients Glossary for more info.
The Research
- Demonstrated to help reduce occasional vocalization associated with stress, such as whining and barking (Inagawa et al., 2005).
- Shown to support calm behavior in dogs when left alone (Inagawa et al., 2005).
- Dietary supplementation of GABA demonstrated to support neurotransmitter balance involved in stress and relaxation (Jiang et al., 2025).
ACTIVE INGREDIENTS PER CHEW, (3g)
- Relora® – 75mg
- Chamomile Extract – 50mg
- GABA (Gamma-Aminobutyric Acid) – 35mg
- L-Tryptophan – 35mg
INACTIVE INGREDIENTS
- Apple Cider Vinegar, Brewers Dried Yeast, Coconut Glycerin, Coconut Oil, Dried Whey, Honey, Mixed Tocopherols, Molasses, Pollock Oil, Pork Spray Dried Liver, Rosemary Extract, Sunflower Lecithin, Tapioca Starch.
Check out our Ingredients Glossary for more info.
The Research
- Shown to support a normal inflammatory response and promote overall physiological balance associated with well-being (Zhu et al., 2019).
- Supplementation has been associated with supporting calm behavior and balanced activity levels in dogs during periods of environmental stress (Sofyan, 2024).
- Research suggests L-tryptophan helps maintain normal serotonin pathways involved in mood and stress response (Höglund et al., 2017; Yue et al., 2017).
- Supports healthy coping behavior and emotional balance during routine stressors (Höglund et al., 2017).
ACTIVE INGREDIENTS PER CHEW, (3g)
- Relora® – 75mg
- Chamomile Extract – 50mg
- GABA (Gamma-Aminobutyric Acid) – 35mg
- L-Tryptophan – 35mg
INACTIVE INGREDIENTS
- Apple Cider Vinegar, Brewers Dried Yeast, Coconut Glycerin, Coconut Oil, Dried Whey, Honey, Mixed Tocopherols, Molasses, Pollock Oil, Pork Spray Dried Liver, Rosemary Extract, Sunflower Lecithin, Tapioca Starch.
Check out our Ingredients Glossary for more info.
Quality You Don’t Have to Question
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With Globally Sourced Ingredients
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Batch Tested
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No Artificial Colors or Flavors
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GMO, Hormone & Antibiotic free
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GMP/SQF Certified
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In line with FDA CVM Guidelines
Proudly NASC-Certified
Tested for quality
All supplements are rigorously tested and audited
Trusted ingredients
Only high-quality, traceable ingredients
Manufactured safely
We follow Good Manufacturing Practices for consistency.
Trust in every tub
The NASC Seal guarantees uncompromised quality
Clear and transparent
Our labels give you full transparency about ingredients.
Scientifically formulated
Formulated using the latest nutritional science for maximum efficacy
These reviews are for informational purposes only. The information is not a substitute for expert veterinary care. Reviews are written by actual customers and represent their own observations. These observations are not guaranteed, are not medically substantiated, and may not be typical for other pets. When necessary, reviews will be replied to privately.
- NPNorma P.Verified ReviewerReviewingCalming ChewsI recommend this productPet Age 7-9 years oldPet Size 20-40lbsRated 5 out of 5 stars3 months agoPups approve!
My picky pups enjoy these chews and do not turn their nose up at them! We take them at bedtime and it helps us have a calm sleep routine. Would recommend!
- NPNancy P.Verified ReviewerReviewingCalming ChewsI recommend this productPet Age 1-3 years oldPet Size 40-60lbsRated 5 out of 5 stars3 months agoThese chews are effective and apparently taste good too!
We were sent a container of these chews for a dog that we sadly lost unexpectedly to cancer and bloat. She was a dreamboat and we adored her. We accepted the chews because we have 10 dogs and knew they would be useful...they were!
We got 2 young German Shepherd/Husky mix fosters, Momma and Son, and they needed grooming badly. I gave them chews based on their weight before their grooming appointment and the groomer said they were the "best Husky mixes she's ever had!" I took that as a sign that the chews did their job! Both of them gobbled the chews up, so the taste must be pretty yummy.
We have been using Wuffes products for years and I stand by their effectiveness and quality.
- MSMarc S.Verified ReviewerReviewingCalming ChewsI recommend this productPet Age 10-12 years oldPet Size Over 100lbsRated 5 out of 5 stars3 months agoLarge Senior Dog
My 150 LB dog, Camo is not very active in his later stage, but at times he would tend to seem a bit anxious about seeing being alone when I would leave for work. The effects from the calming chews seem to take the edge off and put him in a more relaxed content mood. I think that I additionally see him being a little happier. I do not give him the chews daily, only occasionally. He had never been a dog that gets wound up with noses or lots of activity outside, so I cannot attest to having a sedative effect to address a hyper sensitive temperament. It's reassuring to be able to give a product with natural ingredients, as opposed to prescribed medication. Camo has been on Wuffes joint supplement for years and I truly believe that they have provided relief and added longevity to his big boned, sore joint life. I certainly recommend this product!
- KLKim L.Verified ReviewerReviewingCalming ChewsI recommend this productPet Age 4-6 years oldPet Size 60-80lbsRated 5 out of 5 stars3 months agoAmazing!!
Our beautiful girl was previously abused. She was so skittish over the smallest noises. We have been giving them periodically to her. She's more relaxed. Thank you so much for the opportunity to try these.
- KKKasey K.Verified BuyerReviewingCalming ChewsI recommend this productPet Age 7-9 years oldPet Size 60-80lbsRated 5 out of 5 stars3 months ago10 Paws Up!!!
While two of my dogs experience anxiety, all five of my dogs liked the taste and thought that they were treats! They were easy to break apart of needed for smaller dogsFor my anxious dogs, it is a gentle, non-sedating calming support that definitely took the edge off. I noticed a difference in their behavior about two weeks into a daily dosage routine. Wuffes Calming Chews were much more effective other brands that I have tried in the past. I would definitely recommend them and continue my subscription!
FAQS
For all product FAQs please head to our FAQs page
How many should I give my pup?
Use your pet’s weight to follow the recommended amount below:
Weight Category | Directions for Use |
0-35lbs | 1 soft chew daily |
36-65lbs | 2 soft chews daily |
66-100lbs | 3 soft chews daily |
101-120lbs | 4 soft chews daily |
121+lbs | 5 soft chews daily |
How can it benefit my dog?
Our expertly formulated Calming Chews contain four clinically validated ingredients to support your pup’s everyday stress and occasional anxiety – without the strong sedatives.
Here’s how our calming chews can help:
- Promotes relaxation, without sedation
- Supports emotional balance and stress regulation
- Helps promote calm behavior
- Maintains normal cortisol levels
- Supports healthy neurotransmitter activity (serotonin, GABA, dopamine)
Our chews are ideal for dogs who struggle with:
- Occasional separation anxiety
- Noise sensitivity (like fireworks or thunderstorms)
- Travel or unfamiliar environments
- General restlessness, pacing or hyper-alertness
Whether it's for a specific event or everyday stress, Calming Chews can help your dog stay cool, calm and confident.
How should it be stored?
Our Calming Chews are shelf stable and can be stored in your cupboard at room temperature for up to 3 months. If you intend to use the chews beyond 3 months, we recommend storing your chews in the fridge to preserve their freshness.
Does it contain any allergens?
In order to look out for as many pups as possible, we formulated our chews with allergies in mind. If your pet is particularly sensitive, please note that Calming Chews includes Pork, Fish (wild Alaskan pollock oil) and Brewer’s Yeast (gluten).
Can my pet overdose?
Our Calming Chews are formulated with safe, well-tolerated ingredients. However, exceeding the recommended dose may cause mild digestive upset. Always follow the feeding guide and consult your vet before giving additional doses. If your pet accidentally consumes more than the recommended dose, monitor for symptoms and consult your veterinarian if concerns arise.
What happens if my pup eats them all at once?
If your dog eats too many all at once, you can expect your dog to have minor issues such as gastrointestinal discomfort, including gas and bloating. These symptoms should subside in 2-3 days. If your dog has persistent vomiting and diarrhea, please consult your veterinarian. Your vet will make recommendations based on your pet’s age, size and pre-existing conditions.
Where is it made?
Our products are proudly made in the USA from globally sourced ingredients.
How do I know if my pet needs a calming supplement?
Every dog gets a little anxious now and then - but if your pup regularly seems unsettled, it could be a sign they need some extra support. Our Calming Chews are a gentle way to help ease those everyday stresses.
Here are some common signs your dog may benefit from Wuffes Calming Chews:
- Pacing or struggling to relax
- Whining, barking, or howling for no clear reason
- Easily startled or always on alert
- Shaking or trembling (not from cold)
- Panting even when calm or cool
- Hiding or trying to escape certain situations
- Chewing, digging, or scratching when left alone
- Changes in appetite - eating much more or much less
- Repetitive behaviors like constant licking or tail chasing
- Accidents indoors despite being house-trained
If you’re noticing any of these, it might be time to talk with your vet about adding a calming supplement to your dog’s routine. Many pet parents find that even small changes can make a big difference in their dog’s comfort and behavior.
Can it be used with other supplements or prescription medication?
Yes, Wuffes Calming Chews can generally be used alongside other supplements or medications. However, it’s always best to consult your veterinarian if your dog is taking prescription drugs, especially for behavioral or neurological conditions.
Is it safe for cats?
Wuffes Calming Chews is specifically formulated for dogs and has not been tested for safety or efficacy in cats. Because cats have different metabolic and neurological responses to supplements, particularly to ingredients like GABA (Gamma-Aminobutyric Acid), Chamomile and Relora®, we do not recommend giving this product to cats unless directed by a veterinarian.
*Relora® is used under license.
What are the ingredients?
Active Ingredients per Chew (3g)
Relora® (Propietary blend of Magnolia officinalis and Phellodendron amurense) – 75mg
Chamomile Extract – 50mg
GABA (Gamma-Aminobutyric Acid) – 35mg
L-Tryptophan – 35mg
Inactive Ingredients
Apple Cider Vinegar, Brewers Dried Yeast, Coconut Glycerin, Coconut Oil, Dried Whey, Honey, Mixed Tocopherols, Molasses, Pork Spray Dried Liver, Rosemary Extract, Tapioca Starch, Pollock Oil, Sunflower Lecithin.
*Relora® is used under license.
Where can I find my account?
(Note: An account will only be available if you've completed your purchase as a "subscription." One-time orders will not create an account.)
1. You can click on the user icon on the top right of the page - right next to the shopping cart.
Alternatively, you can also access through the "Manage my subscription" option available in our "Help Center".
3. Enter the email associated with your Wuffes purchase , and a 1 time login code will be sent to your email address. Please make sure to check on your Spam folder!
4. Enter the code, and you are all set!
💡 Troubles signing in? We highly recommend clearing the cookies & cache on your web browser, as well as your browsing history, restart your web browser and try to log in one more time!
💡 Not receiving the verification code? Do not worry! The verification code may sometimes be detected as "spam" by your email's filtering system, so please make sure to check your spam folder!
Where are your products made?
We’re proud to say that every Wuffes product is made right here in the USA—crafted with care and held to the highest quality standards. We use a mix of domestically and globally sourced ingredients, carefully selected for their safety, effectiveness, and benefits for your pup’s health.
From production to packaging, we’re committed to delivering trustworthy supplements that you (and your dog) can feel good about.
How long do orders take to ship?
We know your furry friend can't wait to receive their Wuffes, and with all that tail-waggling, all they mean is "Is it here yet?!". Don't worry, we won’t keep you waiting! All orders placed before noon are shipped on the same day, while all other orders will ship within 1 business day.
| Time your order is placed | Shipping time |
| Before 12:00 pm (midday) | Shipped the same day |
| After 12:00 pm (midday) | Shipped within 1 business day (Monday–Friday, except Holidays) |
e.g. If your order is placed on a Friday at 9:00 am, your order will be shipped the same day. If your order is placed on a Friday at 2:00 pm, your order will be shipped until the next Monday.
Where are your products shipped from?
Where Does Wuffes Ship From?
Wuffes orders ship from the USA. We fulfill orders from three warehouses located in Tracy, CA, Addison, IL, and Atlanta, GA.
Can I give Wuffes supplements to a pregnant dog?
More zoomies on the way?
We totally get wanting the best for your mama-to-be! Since our supplements haven’t been tested on pregnant or nursing dogs, we recommend checking with your vet first to make sure it’s the safest choice for her and her pups.
Can my pet overdose?
My dog ate the whole tub—what now?
Don’t panic—we know pups can be sneaky snackers! If your dog polished off an entire tub of our Advanced Hip & Joint Support (as long as it's made for their weight), they should be just fine. You might notice some mild symptoms like vomiting, diarrhea, or an upset tummy.
If they got into more than one tub, a tub for a different weight or symptoms last longer than 24 hours, it’s best to check in with your vet just to be safe. And of course, we’re here if you need us!
In the case of our 23-in-1 Multivitamin, certain vitamins (such as Vitamin D3) can cause toxicity in large doses. If you think they’ve eaten too much, it’s always best to be safe and speak to your vet.
Do pets need joint supplements?
Great question! Just like humans, dogs’ joints go through wear and tear—especially as they age, stay active, or belong to larger breeds prone to joint issues. Joint supplements help support mobility, reduce stiffness, and cushion their joints so they can stay active, playful, and pain-free.
Even younger pups can benefit! Starting early can help maintain healthy joints down the line.
How do I know if my pet needs a joint supplement?
With 1 in 5 dogs developing joint issues in their lifetime (reference), it’s very important for pet parents to look out for and recognise signs of joint discomfort. Some signs to look out for include:
- Limping
- Difficulty stand up and/or lying down
- Shaking legs
- Uneven weight bearing and/or favoring one side
These are also very common signs of other issues. If your pet exhibits one or more of these, please consult your veterinarian.
Can it be used with other supplements or prescription medication?
Absolutely! Our joint chews are designed to play nice with other supplements and medications—as long as you’re following the recommended serving guidelines.
If your pup is on a prescription or has a medical condition, a quick check-in with your vet is always a good idea.
We’re so sure you’ll love our products, we offer a 90-day money back guarantee on all our edible supplements.
