Advanced Joint Liquid
473ml / 16 fl oz

Image of Wuffes Advanced Joint Liquid supplement for dogs with UC-II collagen, labeled 'Protect and Repair.' A dog's nose is visible in the background, sniffing the bottle. Three icons are displayed to the right with text: 'Scientifically Formulated,' 'Helps Support Joint Flexibility and Mobility,' and '90 Day Money-back Guarantee.' A banner at the bottom reads 'With UC-II Collagen.'
A promotional graphic for Wuffes Advanced Joint Liquid featuring UC-II Collagen. The text highlights that the product is 'Clinically proven to: reduce pain by 57% and reduce exercise-associated lameness by 53% in only 30 days!' The background is dark green, with a small outline of a dog playing with a ball in the bottom right corner.
Image displaying the benefits of a dog supplement after 90 days of regular use. The headline reads, 'Here's how it can benefit your pup after 90 days of regular use.' Four benefits are shown around the central image of a liquid supplement: 'Enhances Bone & Joint Health,' 'Eases Joint Stiffness Due to Daily Activity,' 'Provides Bone Reinforcing Factors,' and 'Helps Maintain Mobility.' The 'Product Benefits' section is highlighted with a green icon at the top.
A promotional graphic for Wuffes Advanced Joint Liquid with the text 'Tailor Made For Dogs Of All Sizes.' The image shows a happy dog sitting in a kitchen next to a bowl of food and a bottle of the product. To the right, there are dosage recommendations for different dog weights: Under 20lbs - 1 tsp daily, 21-40lbs - 2 tsp daily, 41-60lbs - 3 tsp daily, 61-80lbs - 4 tsp daily, 81-100lbs - 5 tsp daily, and 100lbs+ - 6 tsp daily.
A promotional graphic for Wuffes Advanced Joint Liquid with the headline 'Crafted With Love, Backed By Science.' The text lists key ingredients: Glucosamine, MSM, Chondroitin Sulfate, UC-II Collagen, and 'And so much more!' Below the text is an image of the product bottle surrounded by various healthy ingredients, including a piece of meat, almonds, spinach, and kale. The background is dark green.
A testimonial graphic titled 'Real Results' from Haley & Buttercup, with a photo of a happy dog. The testimonial describes how Wuffes joint liquid transformed Buttercup’s joint health and energy, enabling long daily walks. Below is a 5-star rating on a green background.
A promotional graphic featuring three customer testimonials for Wuffes Advanced Joint Liquid. The first quote mentions a 5-year-old dog being less lethargic and more energetic after two weeks. The second quote states that all three dogs are given Wuffes and show improvement. The third quote notes a noticeable improvement in joint health right away. The background includes a plant, dog bowl, and collar.
Image of Wuffes Advanced Joint Liquid supplement for dogs with UC-II collagen, labeled 'Protect and Repair.' A dog's nose is visible in the background, sniffing the bottle. Three icons are displayed to the right with text: 'Scientifically Formulated,' 'Helps Support Joint Flexibility and Mobility,' and '90 Day Money-back Guarantee.' A banner at the bottom reads 'With UC-II Collagen.'
A promotional graphic for Wuffes Advanced Joint Liquid featuring UC-II Collagen. The text highlights that the product is 'Clinically proven to: reduce pain by 57% and reduce exercise-associated lameness by 53% in only 30 days!' The background is dark green, with a small outline of a dog playing with a ball in the bottom right corner.
Image displaying the benefits of a dog supplement after 90 days of regular use. The headline reads, 'Here's how it can benefit your pup after 90 days of regular use.' Four benefits are shown around the central image of a liquid supplement: 'Enhances Bone & Joint Health,' 'Eases Joint Stiffness Due to Daily Activity,' 'Provides Bone Reinforcing Factors,' and 'Helps Maintain Mobility.' The 'Product Benefits' section is highlighted with a green icon at the top.
A promotional graphic for Wuffes Advanced Joint Liquid with the text 'Tailor Made For Dogs Of All Sizes.' The image shows a happy dog sitting in a kitchen next to a bowl of food and a bottle of the product. To the right, there are dosage recommendations for different dog weights: Under 20lbs - 1 tsp daily, 21-40lbs - 2 tsp daily, 41-60lbs - 3 tsp daily, 61-80lbs - 4 tsp daily, 81-100lbs - 5 tsp daily, and 100lbs+ - 6 tsp daily.
A promotional graphic for Wuffes Advanced Joint Liquid with the headline 'Crafted With Love, Backed By Science.' The text lists key ingredients: Glucosamine, MSM, Chondroitin Sulfate, UC-II Collagen, and 'And so much more!' Below the text is an image of the product bottle surrounded by various healthy ingredients, including a piece of meat, almonds, spinach, and kale. The background is dark green.
A testimonial graphic titled 'Real Results' from Haley & Buttercup, with a photo of a happy dog. The testimonial describes how Wuffes joint liquid transformed Buttercup’s joint health and energy, enabling long daily walks. Below is a 5-star rating on a green background.
A promotional graphic featuring three customer testimonials for Wuffes Advanced Joint Liquid. The first quote mentions a 5-year-old dog being less lethargic and more energetic after two weeks. The second quote states that all three dogs are given Wuffes and show improvement. The third quote notes a noticeable improvement in joint health right away. The background includes a plant, dog bowl, and collar.

Less than 1% of customers claim our Money Back Guarantee

Advanced Joint Liquid
473ml / 16 fl oz

4.9
Rated 4.9 out of 5 stars
33 Reviews
How it Works

Enhances bone & joint health


Helps improve mobility


Provides bone reinforcing factors

Dog size:

Under 20 lbs

Frequency:

Shipped in 24 hours from our USA Warehouse

90 Day Money Back Guarantee

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We recommend at least 3 months of consistent use to see results*

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What to Expect With Wuffes

Here’s some helpful information on how to take Wuffes, and what to expect in the first 90 days of consistent use.

Directions for Use

Under 20lbs

1 tsp daily

21-40lbs

2 tsp daily

41-60lbs

3 tsp daily

61-80lbs

4 tsp daily

81-100lbs

5 tsp daily

Over 100lbs

6 tsp daily

When to expect results

With UC-II© Collagen, clinically-proven to:

57%Reduce pain by 57% in 30 days†

53%Reduce exercise-associated lameness by 53% in 30 days†

†UC-II Combo Supplement; UC-II Mechanism of Action; UC-II Anti-Inflammatory Effects; UC-II Pain Reduction, UC-II Immune Suppression, UC-II vs. Pharma, UC-II Review

What to look out for

Our joint liquid is scientifically-formulated to enhance bone and joint health, so you can expect to see:

Maintained mobility

Visible increase in comfort

Increased eagerness to run and play

More ease jumping onto the couch/bed

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90-Day Money Back Guarantee

Formulated by Pet Scientists

No Artificial Colors or Flavors

Made in USA with Globally Sourced Ingredients

Save on Subscriptions

90-Day Money Back Guarantee

Formulated by Pet Scientists

No Artificial Colors or Flavors

Made in USA with Globally Sourced Ingredients

Save on Subscriptions

Our 4 Pillars of Joint Health

Our products work together to address every aspect of joint health, offering a comprehensive solution to keep your pet active, happy, and healthy.

1. Protect & Support

Choose between our Advanced Hip & Joint Support chews and Advanced Joint Liquid based on your pup’s preferences and levels of discomfort. They’re highly concentrated to protect and actively enhance bone & joint health.

Joint Chews are ideal for daily maintenance, while the Advanced Joint Liquid is for dogs needing more intensive joint care.

2. Nourish

Our Advanced Omega 3 Fish Oil helps relieve inflammation from exercise and aging, promoting the normal production and maintenance of synovial fluid. Rich in EPA and DHA, it nourishes the body with essential fatty acids that support cartilage health and synovial fluid production.

3. Soothe

CBD Isolate Oil targets and eases joint stiffness by relieving inflammation from daily activity. CBD works at a cellular level to reduce inflammatory signals, providing your dog with much-needed alleviation from joint discomfort.

4. Restore

Our low-level light laser therapy stimulates blood flow, to promote faster healing.
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Crafted with Love, Backed
By Science

Our scientifically-proven ingredients have been scrutinized in thousands of studies, and are meticulously selected for their combined effect to enhance joint health & mobility.

Glucosamine

Protect & Support

Glucosamine is naturally produced in the body to maintain the health of the cartilage within joints. Glucosamine can help build lost cartilage by stimulating chondrocytes in the joint. It also helps maintain the integrity of the synovial fluid, enhancing mobility and reducing occasional stiffness.

Featured In:

Advanced Hip & Joint Support

Advanced Joint Liquid

The Research
Read more about the science behind our ingredients in our Ingredients Glossary. 

Full Ingredients

Active Ingredients per Ounce

  • Total Glucosamine 1600mg (Glucosamine HCI 800mg, Glucosamine Sulfate 800mg)
  • MSM 1500mg
  • Chondroitin Sulfate 1500mg
  • Eggshell Membrane 600mg
  • Boswellia Serrata Extract (65% Boswellic Acid) 600mg
  • Green Tea Extract (50% Polyphenols; 30% Catechins, 15% ECGC) 600mg
  • FruiteX-B® (Calcium Fructoborate) 300mg
  • UC-II® Collagen 80mg

Inactive Ingredients

Purified Water, Powdered Cooked Beef Natural Flavor, Glycerin, Potassium Sorbate, Vitamin E.

Real Results from Real Vets and Customers

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The Proof is in the Progress

We’re trusted by thousands of pet parents just like you.

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  • This Stuff Works!!

    At week 4 we now have seen our primary vet and stopped all meds and started acupuncture along with the joint liquid. His mobility is great, he shows no signs of pain and he wants to run and play like his old self.

    Donald A.

  • I Saw the Difference

    Since I have started to give my dogs this every morning I have seen a huge improvement in their lives. Both seem happier. Not as tired. My pitbull has not been limping at all. I think she has a torn

    ACL and it's given her problems for years and I finally see her very active and not in pain. 

    Brenda P.

  • My Dog Loves It

    My dog loves the joint liquid and it helps his joints!! Noticeable difference right away!

    Miranda F.

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Quality You Don’t Have to Question

  • With Globally Sourced Ingredients

  • Batch Tested

  • No Artificial Colors or Flavors


  • GMO, Hormone & Antibiotic Free

  • GMP/SQF Certified

  • In Line with FDA CVM Guidelines

FAQS

For all product FAQs please head to our FAQs page

What are full ingredients

Active Ingredients (per oz)

Total Glucosamine 1600mg (Glucosamine HCI 800mg & Glucosamine Sulfate 800mg), MSM 1500mg, Chondroitin Sulfate 1500mg, Eggshell Membrane 600mg, Boswellia Serrata Extract (65% Boswellic Acid) 600mg, Green Tea Extract (50% Polyphenols; 30% Catechins, 15% ECGC) 600mg, FruiteX-B® (Calcium Fructoborate) 300mg, UC-II® Collagen 80mg.

Inactive Ingredients

Organic Glycerine, Potassium Sorbate, Powdered Cooked Beef Natural Flavor, Purified Water, Vitamin E.

Caution: If animal's condition worsens or does not improve, stop product administration and consult your veterinarian. Safe use in pregnant animals or animals intended for breeding has not been proven. Administer during or after the animal has eaten to reduce incidence of gastrointestinal upset. An examination from a veterinarian is recommended prior to using this product.

How much should I give my pet?

Use your pet’s weight to follow the daily recommended guidelines below. We recommend that you feed it with or after one of their daily meals. For the first 4 weeks, consider splitting the recommended amount in half and giving it over two different times. This will help your pet adjust to this addition to their diet. 

How old does my dog have to be?

Our joint liquid is suitable for pets over 6 months of age.

How can it benefit my dog?

Designed to enhance joint health, our powerful formula helps reduce discomfort while enhancing joint mobility. It features scientifically-proven ingredients like Glucosamine, MSM, Chondroitin Sulfate, UC-II® Collagen, Egg Shell Membrane, FruiteX-B®, Boswellia Serrata and Green Tea Extract. Together, these ingredients offer a multi-faceted approach to joint health, enhancing the structural integrity of joints and connective tissue in dogs of all ages.  Our liquid formula is designed to:

  • Enhance bone & joint health
  • Ease joint stiffness due to daily activity
  • Provides building blocks for synovial fluid, cartilage and connective tissues 
  • Enhances tissue pliability 
  • Provides bone reinforcing factors

How should it be stored?

Our Advanced Joint Liquid can be stored at room temperature for up to three months. For optimum freshness, we recommend storing it in the fridge.

Does it contain any allergens?

Our formula contains cooked beef powder and should not be used in animals with beef allergies or sensitivities. 

Can my pet overdose?

Our Advanced Joint Liquid contains active compounds which can cause gastrointestinal upset when consumed in large doses. If your pet consumes more than they should, you may see loose stools and/or minor vomiting for a day or so. These symptoms subside quickly but should they persist, please consult your vet.

Where is it made?

Our products are proudly made in the USA from globally-sourced ingredients. 

Do pets need joint supplements?

Joint supplements are important because they help support and maintain joint health, particularly in aging dogs. They can also be beneficial for breeds that are prone to joint discomfort as they help maintain normal healthy cartilage and joint function.

How do I know if my pet needs a joint supplement? 

With 1 in 5 dogs developing osteoarthritis in their lifetime (reference), it’s  very important for pet parents to look out for and recognise signs of joint discomfort. Some signs to look out for include:

  • Limping or favoring a limb
  • Stiffness, especially after rest
  • Reluctance to move, jump, or climb stairs
  • Difficulty rising from a lying down position
  • Swelling or visible deformity around joints
  • Audible clicking or popping sounds when moving
  • Reluctance to exercise
  • Visible signs of pain such as whimpering or yelping
  • Changes in posture or gait
  • Visible signs of discomfort when touched around joints
  • These symptoms are also very common signs of other diseases or disorders.


If you observe your pet to have one or more of these symptoms, please consult your veterinarian.

Can it be used with other supplements or prescription medication?

Absolutely. As long as you follow our dosage guidelines, our joint liquid can be safely used in conjunction with other supplements, including any NSAIDs that your vet may have prescribed for your pet’s joint disease. If your pet takes prescription medication, always consult your vet before introducing new supplements to your pet’s diet.

How old does my dog have to be?

Our joint liquid is suitable for pets over 6 months old. 

Is it safe for cats?

No, our joint liquid is not cat safe as some ingredients do not have proven safety indices in cats. If you are looking for a cat safe joint supplement, please use our Advanced Hip & Joint Support chews and follow the directions for use for pets between 0-35lbs.

Where can I find my account?

All you have to do is click on the user icon on the top right of the page - right next to the shopping cart.

Where are your products made?

Where are your products made?

How long do orders take to ship?

All orders placed before noon are shipped on the same day, while all other orders will ship within 1 business day. Not to worry, we won’t keep you waiting!

How do I return an item?

If you’re not satisfied with your purchase, please email hello@wuffes.com and our customer service will be happy to help.

Where are your products shipped from?

All our products are made in the USA and shipped from our warehouse in Denver, Colorado.

Can I give Wuffes supplements to a pregnant dog?

Our products haven’t been tested on pregnant or lactating dogs so we recommend speaking to your vet beforehand.
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The Research

Read more about the science behind our ingredients in our Ingredients Glossary

Scroll through what fellow pet parents have to say

4.9
Rated 4.9 out of 5 stars
Based on 33 reviews
Total 5 star reviews: 29 Total 4 star reviews: 4 Total 3 star reviews: 0 Total 2 star reviews: 0 Total 1 star reviews: 0
100%would recommend these products
ResultsRated 4.6 on a scale of 1 to 5
Great TasteRated 4.3 on a scale of 1 to 5
Ease of UseRated 4.7 on a scale of 1 to 5
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33 reviews
  • AD
    Ana D.
    Verified Buyer
    Reviewing
    Advanced Joint Liquid
    I recommend this product
    Pet Age 10-12 years old
    Pet Size 40-60lbs
    Rated 5 out of 5 stars
    1 month ago
    Great Product!

    I have noticed improvement on my older dog's movement and overall attitude. She sleeps better and don't complain about pain as much. We also watch her diet and exercise as often as the weather allows. It's been a game changer!

    ResultsRated 5.0 on a scale of 1 to 5
    Great TasteRated 5.0 on a scale of 1 to 5
    Ease of UseRated 5.0 on a scale of 1 to 5
    Was this helpful?
    Wuffes
    1 month ago

    Hi there,

    Thank you so much for sharing such positive feedback! We’re so happy to hear that your older dog is feeling better—improved movement, better sleep, and less discomfort are such wonderful changes to see! It sounds like you’re doing everything you can to support her health, and we’re so glad Wuffes is part of her wellness routine.

    If you ever have any questions or need assistance in the future, please don’t hesitate to reach out. We’re here to help!

    Wishing your pup many more happy, comfortable days ahead! 🐾

    Best regards,
    The Wuffes Team

  • SO
    Steve O.
    Verified Buyer
    Reviewing
    Advanced Joint Liquid
    I recommend this product
    Pet Age 13 or older
    Pet Size 80-100lbs
    Rated 5 out of 5 stars
    5 months ago
    Karma is a retired K9. She is 17

    It is awesome i couldn’t believe my dog. Is full of piss and vinager again. She’s acting like a puppy. I can’t believe how quick the wuffies start to work. I’m so happy we found this supplement for my karma.

    ResultsRated 5.0 on a scale of 1 to 5
    Great TasteRated 5.0 on a scale of 1 to 5
    Ease of UseRated 5.0 on a scale of 1 to 5
    Was this helpful?
    Wuffes
    5 months ago

    Wow! Karma being 17 and acting like a puppy it's amazing!! We are so happy Wuffes is helping a retired K9 member, thanks for sharing!
    Saul - Cs at Wuffes

  • CG Profile picture for Cecelia G.
    Cecelia G.
    Reviewing
    Advanced Joint Liquid
    I recommend this product
    Pet Age 4-6 years old
    Pet Size Under 20lbs
    Rated 5 out of 5 stars
    5 months ago
    Gracie doing great Advanced Joint Liquid !!!

    First day and three days Gracie is taking the Liquid but the chews are Great!!

    ResultsRated 5.0 on a scale of 1 to 5
    Great TasteRated 5.0 on a scale of 1 to 5
    Ease of UseRated 5.0 on a scale of 1 to 5
    Was this helpful?
    Wuffes
    5 months ago

    Your pup is so adorable! Thanks for trusting us, keep us updated on Gracie's improvement.
    Saul - Cs at Wuffes

  • DA
    Donald A.
    Verified Buyer
    Reviewing
    Advanced Joint Liquid
    I recommend this product
    Pet Age 7-9 years old
    Pet Size 20-40lbs
    Rated 5 out of 5 stars
    6 months ago
    This Stuff Works!!

    Our 7 year old Beagle was diagnosed with Hip Dysplasia last year. Our primary Vet does Chiropractic care and we started him on MovoFlex chews. He was doing pretty good until earlier this year when we started to notice that he was moving slower and starting to limp on his left rear leg. He started getting Adequan shots also. We were not really seeing any improvement and then early last month (Aug 24) he had a bad episode and could barely walk and did not want to put any weight on his left leg. Our primary Vet was not available and we seen one of the other Vets. XRays were performed and after reviewing them, we asked for a referral for hip replacement surgery. In the mean time we were given Gabapentin and Rimadyl to manage the pain until we could get scheduled for our referral which could be 6-8 weeks. We started searching online and my wife happened to find Wuffes. I reviewed the site and decided to try the Joint liquid. Started noticing some improvement to his mobility in about 2 weeks, but was unsure if it was the meds or this supplement. Started weaning him off the Meds and after the third week I am seeing even more improvement. At week 4 we now have seen our primary vet and stopped all meds and started acupuncture along with the joint liquid. His mobility is great, he shows no signs of pain and he wants to run and play like his old self. We have postponed any surgery and hope to not need it now!

    ResultsRated 5.0 on a scale of 1 to 5
    Great TasteRated 5.0 on a scale of 1 to 5
    Ease of UseRated 5.0 on a scale of 1 to 5
    Was this helpful?
    Wuffes
    5 months ago

    That's amazing to hear! We are so happy our Joint Liquid has helped improve your pup's mobility and alleviated their hip dysplasia symptoms. It's incredible to see the transformation from barely being able to walk to running and playing like their old self again. We're thrilled you've been able to postpone surgery and hope the continued use of our product allows your furry friend to live pain-free. Thank you for sharing your heartwarming story!

  • PS
    Pam S.
    Verified Buyer
    Reviewing
    Premium Joint Liquid
    I recommend this product
    Pet Age 10-12 years old
    Pet Size Under 20lbs
    Rated 5 out of 5 stars
    9 months ago
    Definite improvement

    My Dorkie, 8#4oz, 11 yrs old was starting to show hesitation using stairs and jumping on and off the bed. My daughter recommended Wuffes. Maggie was not liking the liquid so I ordered the chews. She didn’t like them either. Now I’m mixing the liquid with a little yogurt and she is good with that. Have definitely seen an improvement with her mobility.

    ResultsRated 4.0 on a scale of 1 to 5
    Great TasteRated 2.0 on a scale of 1 to 5
    Ease of UseRated 2.0 on a scale of 1 to 5
    Was this helpful?
    Wuffes
    9 months ago

    We're overjoyed to learn that our Wuffes have made a noticeable difference in your beloved Maggie's mobility and overall well-being! It's wonderful to hear that your creativity in mixing the liquid supplement with yogurt has found a winning combination that entices her palate. We understand that our furry companions can be particular about their treats, and we're thrilled that you've discovered a method that works for Maggie. Thank you for your trust in our products and for sharing this heartwarming review. It brings us immense joy to know that we're playing a role in helping our four-legged friends maintain their youthful spirits throughout their golden years.

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