Calming Chews
180g / 6.35oz / 60 chews
Promotes relaxation
Reduces hyperactivity
Regulates cortisol
Order within
Order
Today
Ships
Today
Arrives
4 days from now
*Talbott et al., 2013; Landsberg et al., 2017
**Talbott et al., 2013
***Landsberg et al., 2017
Premium, Ethically-Sourced Ingredients
Made in USA
GMP Certified
In line with FDA CVM Guidelines
90 Day Satisfaction Guarantee
Premium, Ethically-Sourced Ingredients
Made in USA
GMP Certified
In line with FDA CVM Guidelines
90 Day Satisfaction Guarantee
Dr. Meghan Barrett
DVM, cVMA, CCRT, CVFT, FFCP, CCVN
Dr. Tiffany Ruiz-Da Silva
VMD, cVMA
Smudge
Wuffes Calming Chew Superfan
Charlie
Wuffes Calming Chew Superfan
Dave
Wuffes Calming Chew Superfan
Here's a crazy statistic for you – almost 50% of dogs suffer from fear and anxiety.*
Things like a simple doorbell ringing, car ride or trip to vet can feel like a complete sensory overload.
So, how can you tell if your pup is stressed out? See if any of the signs below check out:
Barking or Whining
Lip Licking or Tail Chasing
Pacing or Restlessness
Destructive Behaviour
Frequent Peeing Indoors
Hiding or Attempting to Escape
Ears Pinned Back or Tail Tucked
Trembling or Shaking
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Some highly intelligent and sensitive breeds are especially prone to these behaviors:
Some highly intelligent and sensitive breeds are especially prone to these behaviors:Border Collies • German Shepherds • Australian Shepherds • Vizslas • Italian Greyhounds • Chihuahuas • Toy Poodles • Shetland Sheepdogs • Weimaraners
*Source: Texas A&M College of Veterinary Medicine.
Daily Support, Made Simple
Formulated with active ingredients at meaningful doses, every Wuffes chew is designed to deliver real benefits, not empty promises.
Directions for Use
0-35 lbs
1 Soft Chew daily
36-65 lbs
2 Soft Chews daily
66-100 lbs
3 Soft Chews Daily
101-120 lbs
4 Soft Chews Daily
Over 121 lbs
5 Soft Chews Daily
We recommend giving supplements as part of their normal routine
What Are They Stressed About?
Everyday stresses?
Take the chews daily.
Specific stressful situation?
Take the chews 3-4 weeks before for desired effects.
What You'll Start to See
Our chews are scientifically formulated with clinically tested ingredients to bring out the best in your pup.
Promotes relaxation, without sedation
Supports emotional balance and stress regulation
Helps promote calm behaviour
Maintains normal cortisol levels
In a Sea of Products, Why Trust Us?
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EVERYONE ELSE 
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COST PER CHEW |
$0.41 |
$0.44 – $1+ |
CLINICALLY STUDIED AMOUNT |
🧪 |
❌ |
ACTIVES PROVEN TO CALM |
✅ |
❌ |
NASC APPROVED |
✅ |
🤷🏼 |
TOTAL ACTIVE INGREDIENTS PER CHEW |
💪🏻 |
👎 |
MADE IN USA |
✅ |
💩 |
MONEY-BACK GUARANTEE |
✅ |
🤷🏼 |
VETERINARIAN APPROVED |
✅ |
❌ |
The ingredients in our Calming Chews have been scrutinized in thousands of studies, and are meticulously selected for their combined effect to reduce stress and promote calm.
Relora®
Featured In:
Featured In:
Featured In:
Featured In:
The Research
- Significantly reduces cortisol levels in both dogs and humans, helping to downregulate the HPA axis and reduce stress (Talbott et al., 2013; Landsberg et al., 2017).
- Improves mood scores by reducing tension, confusion, and fatigue, while increasing vigor and calmness (Talbott et al., 2013).
- Demonstrated behavioral improvements within days of supplementation in dogs with thunderstorm anxiety (Landsberg et al., 2017 – Solliquin Study).
- Reduces hyperactivity and anxiety-like behavior in response to noise stress (Landsberg et al., 2017).
ACTIVE INGREDIENTS PER CHEW, (3g)
- Relora® – 75mg
L-Theanine – 35mg
L-Tryptophan – 35mg
Chamomile Extract – 50mg
INACTIVE INGREDIENTS
- Apple Cider Vinegar, Brewers Dried Yeast, Coconut Glycerin, Coconut Oil, Dried Whey, Honey, Mixed Tocopherols, Molasses, Pork Spray Dried Liver, Rosemary Extract, Tapioca Starch, Pollock Oil, Sunflower Lecithin.
The Research
- Lowers cortisol levels during acute stress scenarios like thunderstorm exposure, reducing behaviors such as panting, pacing, and hiding (Michelazzi et al., 2010; Pike et al., 2015).
- Dogs treated with L-theanine showed faster recovery after stress and reduced avoidance behaviors, indicating improved emotional resilience (Pike et al., 2015).
- Promotes alpha brain wave activity, linked to a calm but alert mental state (Michelazzi et al., 2010).
- Demonstrated behavioral improvement in storm-sensitive dogs, helping them return to baseline behavior more quickly after stress (Michelazzi et al., 2010).
ACTIVE INGREDIENTS PER CHEW, (3g)
Relora® – 75mg
L-Theanine – 35mg
L-Tryptophan – 35mg
Chamomile Extract – 50mg
*Not recognized as an essential nutrient by the AAFCO Dog Food Nutrient Profile
Calorie Content (ME calculated): 3,375 kcal/kg, 13.5 kcal per chew
INACTIVE INGREDIENTS
- Apple Cider Vinegar, Brewers Dried Yeast, Coconut Glycerin, Coconut Oil, Dried Whey, Honey, Mixed Tocopherols, Molasses, Pork Spray Dried Liver, Rosemary Extract, Tapioca Starch, Pollock Oil, Sunflower Lecithin.
The Research
- Chamomile significantly reduces cortisol and normalizes the diurnal cortisol slope, promoting a stable stress response (Keefe et al., 2017; Alvarado-Garcia et al., 2024).
- Reduces oxidative stress and neuroinflammation, with measurable decreases in ROS and cytokines like IL-1β and IL-6 (Jabri et al., 2022).
- Enhances sleep quality and nighttime relaxation, addressing both stress and sleep disturbance in anxious dogs (Alvarado-Garcia et al., 2024).
- Demonstrates a notable reduction in fear, hyperactivity, and avoidance behavior in dogs with situational anxiety (Saadatmand et al., 2024).
ACTIVE INGREDIENTS PER CHEW, (3g)
Relora® – 75mg
L-Theanine – 35mg
L-Tryptophan – 35mg
Chamomile Extract – 50mg
*Not recognized as an essential nutrient by the AAFCO Dog Food Nutrient Profile
Calorie Content (ME calculated): 3,375 kcal/kg, 13.5 kcal per chew
INACTIVE INGREDIENTS
- Apple Cider Vinegar, Brewers Dried Yeast, Coconut Glycerin, Coconut Oil, Dried Whey, Honey, Mixed Tocopherols, Molasses, Pork Spray Dried Liver, Rosemary Extract, Tapioca Starch, Pollock Oil, Sunflower Lecithin.
The Research
- Shown to reduce pro-inflammatory cytokines (TNF-α, IL-6, IL-1β) and enhance anti-inflammatory markers, supporting emotional balance (Zhu et al., 2019).
- Dogs supplemented with tryptophan exhibit reduced fear and hyperactivity in high-stress environments (Sofyan, 2024).
- Long-lasting effects on brain serotonin and stress responses, persisting beyond the period of supplementation (Höglund et al., 2017; Yue et al., 2017).
- Improves coping mechanisms and emotional stability during routine stressors (Höglund et al., 2017).
ACTIVE INGREDIENTS PER CHEW, (3g)
Relora® – 75mg
L-Theanine – 35mg
L-Tryptophan – 35mg
Chamomile Extract – 50mg
*Not recognized as an essential nutrient by the AAFCO Dog Food Nutrient Profile
Calorie Content (ME calculated): 3,375 kcal/kg, 13.5 kcal per chew
INACTIVE INGREDIENTS
- Apple Cider Vinegar, Brewers Dried Yeast, Coconut Glycerin, Coconut Oil, Dried Whey, Honey, Mixed Tocopherols, Molasses, Pork Spray Dried Liver, Rosemary Extract, Tapioca Starch, Pollock Oil, Sunflower Lecithin.
Quality You Don’t Have to Question
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With Globally Sourced Ingredients
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Batch Tested
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No Artificial Colors or Flavors
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GMO, Hormone & Antibiotic free
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GMP/SQF Certified
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In line with FDA CVM Guidelines
Proudly NASC-Certified
Tested for quality
All supplements are rigorously tested and audited
Trusted ingredients
Only high-quality, traceable ingredients
Manufactured safely
We follow Good Manufacturing Practices for consistency.
Trust in every tub
The NASC Seal guarantees uncompromised quality
Clear and transparent
Our labels give you full transparency about ingredients.
Scientifically formulated
Developed with veterinary professionals to ensure top quality
These reviews are for informational purposes only. The information is not a substitute for expert veterinary care. Reviews are written by actual customers and represent their own observations. These observations are not guaranteed, are not medically substantiated, and may not be typical for other pets. When necessary, reviews will be replied to privately.
- SRSue R.Verified ReviewerReviewingCalming ChewsI recommend this productRated 4 out of 5 stars2 hours agoFlorida Giant Dog Rescue
I work with giant breed dogs on a daily basis and have for years. Working in rescue, we get a lot of dogs with various types of anxiety, some clear after a period of decompression, good nutrition, love, play and vet care. Others need a little something more. I used the calming chews for a mastiff that we have in rescue currently and he has responded well.
- CCarrieVerified ReviewerReviewingCalming ChewsI recommend this productRated 4 out of 5 stars3 hours agoNoticeable Improvement
I have been giving these to my dog for a little less than a month and have noticed a change in her behavior. She is still quite nervous in new situations but seems to be a little more open to new people and situations. Will be interested to see how things progress the longer she's on them!
- KJKerstin J.Verified ReviewerReviewingCalming ChewsI recommend this productRated 5 out of 5 stars11 hours agoLove it
We have a Siberian Husky who is 10 years old. He hasn't slowed down as of yet. I think everyone knows Huskies do not leave the 'raptor' stage at 2 or 3 years old. They keep it going with the chews he seems calmer and more cuddly, which we appreciate. His chaotic approach to other dogs, only while on the lead, has lessened. He is perfectly fine at the dog park, loves other dogs and people, always has.
Loud noises do not seem to bother him as much anymore, like fireworks. Less stress for him is a very good thing.
- KCKasey C.Verified ReviewerReviewingCalming ChewsI recommend this productPet Age 7-9 years oldPet Size 60-80lbsRated 5 out of 5 stars2 days agoAbsolute win with all 5 of my dogs!
I was pleasantly surprised by these calming chews. All five of my dogs enjoyed the taste, which is a huge win on its own since they can be picky. While the chews didn’t completely eliminate their anxiety, they absolutely took the edge off and helped them relax during stressful situations. I noticed they were calmer, more settled, and able to recover more quickly without being drowsy or “out of it.” These chews feel like a gentle, natural support rather than a sedative, which is exactly what I was hoping for. After trying them, we added them to our subscription, and I’ll definitely keep these on hand for times when my dogs need a little extra help staying calm! I definitely recommend them! More effective than other calming chews that I have purchased in the past!
- MMaurisaVerified ReviewerReviewingCalming ChewsI recommend this productRated 5 out of 5 stars28 minutes agoA calm Labrador
This product has helped our lab remain calm and less reactive to outside noises when he is home alone. These chews calm him with out zonking him out. They do what they claim. The first OTC product I have found to do so.
How many chews should I give my dog?
Use your pet’s weight to follow the directions for use below.
How can I benefit my dog?
Our expertly formulated chews contain four clinically proven ingredients to help your pup feel more relaxed and balanced – without the strong sedatives. Whether it’s thunder, travel, new environments, new people or spending time alone, it’s about time they felt less nervous, stressed and out of it. Benefits include:
- Easing signs of anxiety and nervousness
- Supporting calmer behavior in stressful situations, like car rides or visits to the vet.
- Helps regulate the stress hormone, cortisol
- Promotes a healthy, more stable stress response
- Supports mood balancing brain chemicals
- Boosts natural calming neurotransmitters, including serotonin and GABA
- Promotes emotional stability without sedation
- Keep your dog relaxed, but still alert, playful and full of personality
Our chews are ideal for dogs who struggle with:
- Separation anxiety
- Noise sensitivity (including fireworks or thunderstorms)
- Travel or unfamiliar environments
- General restlessness, pacing, or hyperalertness
How should the chews be stored?
Our Calming Chews for dogs are shelf stable unopened for 2 years. You can store them in your cupboard at room temperature for up to 3 months. If you intend to use the chews after 3 months, we recommend storing your chews in the fridge to preserve their freshness.
Do the chews contain any allergens?
In order to look out for as many pups as possible, we formulated our chews with allergies in mind. If you or your pet is particularly sensitive, please note that Calming Chews contain Pork Liver, Fish (Wild Alaskan Pollock Oil) and Brewer’s Yeast (gluten).
Can my dog overdose on these chews?
Our chews are formulated with safe, well tolerated ingredients. However, exceeding the recommended dose may cause mild digestive upset. Always follow the directions for use and consult your vet before starting any new supplement. If your pet accidentally consumes more than the recommended dose, monitor for symptoms and consult your veterinarian if concerns arise.
What happens if my dog eats these chews all at once?
If your dog eats too many all at once, you can expect your dog to have minor issues, such as gastrointestinal discomfort – like gas and bloating. These symptoms should subside in 2-3 days. If your dog has persistent vomiting and diarrhea, please consult your veterinarian. Your vet will make recommendations based on your pet’s age, size and pre-existing conditions.
Where are these chews made?
Our chews are proudly made in the USA from globally sourced ingredients.
How do I know if my dog needs a calming supplement?
Every dog gets a little anxious now and then, but if your pup regularly seems unsettled, it could be a sign they need some extra support. Our Calming Chews are a gentle way to help ease those everyday stresses. Here are some common signs your dog may benefit from our chews:
- Pacing or struggling to relax
- Whining, barking, or howling for no clear reason
- Easily startled or always on alert
- Shaking or trembling (not from cold)
- Panting even when calm or cool
- Hiding or trying to escape certain situations
- Chewing, digging, or scratching when left alone
- Changes in appetite – eating much more or much less
- Repetitive behaviors like constant licking or tail chasing
- Accidents indoors despite being housetrained
If you’re noticing any of these, it might be time to talk with your vet about adding a calming supplement to your dog’s routine. Many dog parents find that even small changes can make a big difference in their dog’s comfort and behavior.
Can these chews be used with other supplements or prescription medication?
Yes. These chews can generally be used alongside other supplements or medications. However, we recommend consulting your veterinarian if your dog has pre-existing conditions or is taking prescription drugs before starting any new supplement.
How old does my dog have to be to eat these chews?
These chews are suitable for pets over 6 months of age.
My dog has a health condition, are these chews suitable for them?
Our chews are formulated with gentle, well tolerated ingredients and are typically safe for dogs with common health conditions. Still, we recommend checking with your veterinarian before use, particularly if your dog has a chronic illness or is on medication.
Are these chews safe for cats?
These chews are specifically formulated for dogs and have not been tested for safety or efficacy in cats.
Cats have different metabolic and neurological responses to supplements, particularly to ingredients like L-Theanine, Chamomile, and Relora®. We do not recommend giving this product to cats unless specifically directed and approved by a veterinarian.
Where is it made?
Our products are proudly made in the USA from globally sourced ingredients.
Do pets need joint supplements?
Joint supplements are important because they help support and maintain joint health, particularly in aging dogs or those with specific joint-related issues. They can also be beneficial for younger pups, especially larger dogs and breeds that are prone to joint issues.
Can it be used with other supplements or prescription medication?
Absolutely. As long as you follow our directions for use, our joint chews should not interfere with other supplements or prescription medications.
Where can I find my account?
All you have to do is click on the user icon on the top right of the page - right next to the shopping cart.
Where are your products made?
We’re proud to say all of our products are made in the USA with domestically and globally sourced ingredients.
How long do orders take to ship?
All orders placed before noon are shipped on the same day, while all other orders will ship within 1 business day. Not to worry, we won’t keep you waiting!
How do I return an item?
If you’re not satisfied with your purchase, please email hello@wuffes.com and our customer service will be happy to help.
Where are your products shipped from?
All our products are made in the USA and shipped from our warehouse in Denver, Colorado.
Can I give Wuffes supplements to a pregnant dog?
Our products haven’t been tested on pregnant or lactating dogs so we recommend speaking to your vet beforehand.
We’re so sure you’ll love our products, we offer a 90-day money back guarantee on all our edible supplements.
